Evidence map›Paper›PMID 40880858›Full record

ArticleSkin appendage disorders2025

Oral Minoxidil Use in Yellow Nail Syndrome: Report of 2 Cases.

Karishma Desai, Hadar Lev-Tov, Brian W Morrison

Abstract readCase Reports
In one paragraph

Article in Skin appendage disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karishma DesaiDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Hadar Lev-TovDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Brian W MorrisonDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Yellow nail syndrome (YNS) is a rare disorder characterized by a triad of thickened yellow nails, primary lymphedema, and chronic respiratory manifestations. A key feature of the condition is diminished nail growth which contributes to the development of the characteristic yellow nails. Although its underlying etiology is unclear, it is postulated that microvasculopathy, lymphatic dysfunction, and protein leakage are involved. Current treatment options are limited and do not demonstrate consistent efficacy. Case Reports: We report 2 cases of YNS which improved with treatment using oral minoxidil for 3-6 months. Conclusion: Oral minoxidil therapy was well tolerated and resulted in visible improvement in nail changes. To our knowledge, oral minoxidil therapy for YNS has not previously been reported and may represent a promising new treatment.

Indexed as

Case reportDrug responseGeneral dermatologyMedical dermatologyMinoxidilNail disorders

Identifiers

PMID40880858
PMCPMC12187165

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.