Evidence map›Paper›PMID 40880853›Full record

ArticleFrontiers in neuroscience2025

Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.

Po-Chun Liu, Shao-Ying Cheng, Chih-Chi Li, Yu-Ke Wang, Yufeng Jane Tseng, Ming-Che Kuo

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Po-Chun LiuCathay General Hospital, Taipei, Taiwan.
Shao-Ying ChengDepartment of Neurology, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan.
Chih-Chi LiGraduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan.
Yu-Ke WangGraduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan.
Yufeng Jane TsengGraduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan.
Ming-Che KuoDepartment of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The alterations in the gut microbial network in multiple system atrophy (MSA) remain poorly understood. This study aimed to identify key gut microbial interaction networks in MSA through comprehensive multimodal analyses. Methods: Demographic information and frozen fecal specimens were collected from 119 participants [MSA, Results: We consistently observed lower levels of Conclusion: Future studies are warranted to determine whether fecal microbiome-derived signatures can serve as reliable biomarkers for MSA.

Indexed as

16S rRNAcorrelation and network analysesdifferential abundance analysesgut microbiomemultiple system atrophyParkinson’s disease

Identifiers

PMID40880853
PMCPMC12380817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.