ArticleAnnals of the Child Neurology Society2025
Symptom Onset in Classic Rett Syndrome: Analysis of Initial Clinical Severity Scale Entries.
Article in Annals of the Child Neurology Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Trajectory of skill acquisition, loss, and regain in females with classic Rett syndrome.Journal of neurodevelopmental disorders · 2026Article
- Trajectory of skill acquisition, loss, and regain in females with classic Rett syndrome.Research square · 2025Article
- Prominent Self-Injurious Behavior Masking the Diagnosis of Rett Syndrome: A Case Report from a Resource-Limited Setting.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Objective: To assess clinical features of Rett Syndrome (RTT) at registration into the NIH-sponsored Natural History (NH) study using the Clinical Severity Scale (CSS). Introduction: The CSS was established in 2000 to assess characteristics of individuals with RTT and related disorders. We analyzed the CSS at enrollment into the NH study of all individuals with classic RTT. Methods: The CSS of 1258 individuals was utilized to examine three historical items (age at regression, age at onset of hand stereotypies, and head growth) and ten clinical features at initial enrollment. Results: Among historical items, age at regression was most prominent after age 12 months with 8% regressing prior to this, hand stereotypies were most common after 18 months with 30% occurring before, and head growth was substantially lower overall. Hand use, ambulation, and communication skills were reduced in most. Discussion and Conclusion: These findings reflect core clinical criteria for classic RTT and mirror the top concerns registered independently by parents or caregivers. The CSS is an important analytic tool for association of relative differences in clinical outcome with specific
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Registered trials
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