Evidence map›Paper›PMID 40880841›Full record

ArticleAdvanced functional materials2024

Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development.

Keying Chen, Bingchen Wu, Daniela Krahe, Alberto Vazquez, James R Siegenthaler, Robert Rechenberg, Wen Li, X Tracy Cui, Takashi D Y Kozai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Chronic alteration of CabioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keying ChenDepartment of Bioengineering, Center for the Basis of Neural Cognition.
Bingchen WuDepartment of Bioengineering, Center for the Basis of Neural Cognition.
Daniela KraheDepartment of Bioengineering, Center for the Basis of Neural Cognition.
Alberto VazquezDepartment of Bioengineering, Center for the Basis of Neural Cognition.
James R SiegenthalerDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering and Institute for Quantitative, Health Science and Engineering, Fraunhofer USA Center Midwest, 1449 Engineering Research Ct., B100, East Lansing, MI 48824, USA.
Robert RechenbergDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering and Institute for Quantitative, Health Science and Engineering, Fraunhofer USA Center Midwest, 1449 Engineering Research Ct., B100, East Lansing, MI 48824, USA.
Wen LiDepartment of Electrical and Computer Engineering, Department of Biomedical Engineering and Institute for Quantitative, Health Science and Engineering, Fraunhofer USA Center Midwest, 1449 Engineering Research Ct., B100, East Lansing, MI 48824, USA.
X Tracy CuiDepartment of Bioengineering, Center for the Basis of Neural Cognition.
Takashi D Y KozaiDepartment of Bioengineering, Center for the Basis of Neural Cognition.

Funding

Efficiency and Safety of Microstimulation Via Different Electrode MaterialsR01NS110564 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2024
$3.1M
Subcellular Wireless Axons for in vivo Localized Neuronal ExcitationR01NS105691 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Takashi Daniel Yoshida Kozai, Wen Li · 2020 to 2026
$3.1M
NINDS NIH HHS R01 NS105691NINDS NIH HHS R01 NS110564
6 · The paper itself

Abstract

Neuromodulation technologies have gained considerable attention for their clinical potential in treating neurological disorders and advancing cognition research. However, traditional methods like electrical stimulation and optogenetics face technical and biological challenges that limit their therapeutic and research applications. A promising alternative, photoelectric neurostimulation, uses near-infrared light to generate electrical pulses and thus enables stimulation of neuronal activity without genetic alterations. This study explores various design strategies to enhance photoelectric stimulation with minimally invasive, ultrasmall, untethered carbon electrodes. Employing a multiphoton laser as the near-infrared (NIR) light source, benchtop experiments are conducted using a three-electrode setup and chronopotentiometry to record photo-stimulated voltage. In vivo evaluations utilize Thy1-GCaMP6s mice with acutely implanted ultrasmall carbon electrodes. Results highlighted the beneficial effects of high duty-cycle laser scanning and photovoltaic polymer interfaces on the photo-stimulated voltages by the implanted electrode. Additionally, the promising potential of carbon-based diamond electrodes are demonstrated for photoelectric stimulation and the application of photoelectric stimulation in precise chemical delivery by loading mesoporous silica nanoparticles (SNPs) co-deposited with polyethylenedioxythiophene (PEDOT). Together, these findings on photoelectric stimulation utilizing ultrasmall carbon electrodes underscore its immense potential for advancing the next generation of neurostimulation technology.

Indexed as

boron-doped diamond electrodesconducting polymersintracortical microstimulationmicroelectrodesnanoparticlesneuronal activationoptoelectrical stimulation

Identifiers

PMID40880841
PMCPMC12382601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.