Evidence map›Paper›PMID 40880773›Full record

ArticleFrontiers in medicine2025

Decreased vasoregulatory dysfunction associated with intra-operative hemoadsorption treatment is related to mitigated post-transplant procalcitonin rather than cytokine or complement response.

Hajna Katona, Adam Soltesz, Eniko Kovacs, Zsofia Szakal-Toth, Eszter Tamaska, Kristof Racz, Tamás Radovits, Attila Fintha, Krisztián Kovács, Lisa Hurler and 3 more

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In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03145441 (The Impact of Pre-emptive Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03145441 nacompletednot on this map

The Impact of Pre-emptive Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation

TypeinterventionalSponsorSemmelweis UniversityRan2018 to 2021Enrolled60ConditionsCardiac Transplantation, Cardiopulmonary BypassArmsCytoSorb®
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hajna KatonaHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Adam SolteszHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Eniko KovacsHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Zsofia Szakal-TothHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Eszter TamaskaHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Kristof RaczHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Tamás RadovitsHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Attila FinthaDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Krisztián KovácsDepartment of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
Lisa HurlerDepartment of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.
Zoltán ProhászkaDepartment of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.
Bela MerkelyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Endre NemethHeart and Vascular Center, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of this study was to investigate the modulatory effect of intraoperative hemoadsorption (HA) versus standard care on the perioperative inflammatory profile of patients undergoing orthotopic heart transplantation (OHT) and its correlation with the severity of post-transplant vasoregulatory dysfunction. Methods: In this secondary analysis, data from NCT03145441, a prospective, single-center, open-label, randomized controlled trial were used. Results: Patients in the HA group had a lower median vasopressor score, rate of severe vasoregulatory dysfunction (vasopressor score: 19.7 [7.9-37.8] vs. 35.6 [14.5-57.6], Discussion: Intraoperative HA treatment exerts a beneficial modulatory effect on the postoperative PCT response in OHT recipients, which is directly associated with significantly lower rates of post-transplant severe vasoregulatory dysfunction compared to controls.

Indexed as

complement systemcytokinesCytoSorbheart transplantationhemoadsorptionprocalcitoninvasopressor score

Identifiers

PMID40880773
PMCPMC12380626

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Registered trials

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