ArticleFrontiers in medicine2025
A comparative analysis of cardiopulmonary features in patients with systemic sclerosis and mixed connective tissue disease: results from SOPHIE registry.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: We aimed to identify various cardiopulmonary involvement patterns in patients with systemic sclerosis (SSc) and mixed connective tissue disease (MCTD). Methods: Laboratory experiments, pulmonary function test, 6-min walk distance (6MWD), transthoracic echocardiography, and 12-lead electrocardiography were used to evaluate cardiopulmonary function in patients with SSc and those with MCTD.. Results: A total of 138 patients with SSc and 56 patients with MCTD were enrolled in the study. Patients in the MCTD group exhibited a higher systolic blood pressure (SBP) (128.73 ± 16.82 vs. 121.95 ± 21.22, Conclusion: In this cross-sectional analysis, we found small airway dysfunction in patients with SSc and impaired left ventricular systolic function in patients with MCTD. These findings indicate that there is significant heterogeneity in the cardiopulmonary involvement patterns, although these patterns are both connective tissue diseases with similar disease duration and comorbidity burden.
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