Evidence map›Paper›PMID 40880752›Full record

ArticleFrontiers in parasitology2025

Molecular diagnosis of Chagas disease in patients with megaesophagus exhibiting negative or inconclusive serological results.

Angelica Martins Batista, Tycha Bianca Sabaini Pavan, Eros Antonio de Almeida, Daniel Maximo Corrêa de Alcantara, Paula Durante Andrade, Luiz Cláudio Martins, Jamiro da Silva Wanderley, Sandra Cecília Botelho Costa, Gláucia Elisete Barbosa Marcon

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Article in Frontiers in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angelica Martins Batista *Center of Biological and Health Sciences, Estácio de Sá University, Rio de Janeiro, RJ, Brazil.
Tycha Bianca Sabaini Pavan *Advanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, BA, Brazil.
Eros Antonio de AlmeidaGrupo de Estudos em Doença de Chagas (GEDoCh), Department of Medical Clinic, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, SP, Brazil.
Daniel Maximo Corrêa de AlcantaraOswaldo Cruz Foundation Mato Grosso do Sul, Campo Grande, MS, Brazil.
Paula Durante AndradeLaboratory of Diagnosis of Infectious Diseases by Molecular Biology Techniques, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Luiz Cláudio MartinsGrupo de Estudos em Doença de Chagas (GEDoCh), Department of Medical Clinic, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, SP, Brazil.
Jamiro da Silva WanderleyGrupo de Estudos em Doença de Chagas (GEDoCh), Department of Medical Clinic, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, SP, Brazil.
Sandra Cecília Botelho CostaLaboratory of Diagnosis of Infectious Diseases by Molecular Biology Techniques, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Gláucia Elisete Barbosa MarconOswaldo Cruz Foundation Mato Grosso do Sul, Campo Grande, MS, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagasic megaesophagus is a relatively uncommon clinical manifestation in individuals with chronic Chagas disease (CD), and it has not been extensively documented in literature. However, individuals may exhibit negative or inconclusive serology for CD. This study aimed to assess the performance of molecular diagnostics for CD in participants with these conditions. This was a prospective cohort study that included 26 participants with negative or inconclusive conventional CD serology (Group I), 33 participants with positive CD serology and megaesophagus (Group II), and 10 participants with negative serology and no CD epidemiological history (Group III). Blood samples were collected for serological tests (ELISA and IFAT), blood cultures, and molecular tests like nested PCR (nPCR) targeting Sat-DNA and kDNA, as well as quantitative PCR (qPCR) of

Indexed as

Chagas megaesophagusinconclusive serologymolecular diagnosticnegative serologynPCRqPCR

Identifiers

PMID40880752
PMCPMC12380845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.