ArticleFrontiers in nutrition2025
Effects of glycerol hyperhidration on the running economy of long-distance runners: a randomized crossover clinical trial.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06818253 (Effects of Glycerol Hyperhydration on Running Economy in Long-Distance Runners), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Glycerol Hyperhydration on Running Economy in Long-Distance Runners
Who cites it
2 citing papers in PubMed.
- Absolute Aerobic Capacity Predominates over Body Composition and Regional Anthropometry in Explaining Maximal Fat Oxidation in National-Team Collegiate Athletes: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2026Article
- Post exercise hydration responses to an electrolyte, glycerol, and creatine supplement in horses: a preliminary study.BMC veterinary research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endurance athletes experience significant water loss during exercise, which can impair performance and increase the risk of dehydration. Glycerol hyperhydration has been explored as a strategy to enhance pre-exercise hydration, particularly when fluid intake opportunities are limited. This study aimed to evaluate the effects of glycerol hyperhydration on running economy (RE) in trained runners. Methods: A randomized crossover clinical trial was conducted with 30 trained runners (15 men, 15 women) across three sessions. In the first session, peak oxygen uptake (VO Results: Glycerol supplementation significantly improved running economy, reducing CCU ( Conclusion: These findings indicate that glycerol supplementation enhances key metabolic and physiological factors associated with running economy, including CCU, OCU, cardiovascular responses, and perceived exertion in trained runners. Clinical trial registration: https://clinicaltrials.gov, identifier: NCT06818253.
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Registered trials
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