Evidence map›Paper›PMID 40880735›Full record

ArticleFrontiers in nutrition2025

Increase in circulating GLP-1 following low FODMAP diet in irritable bowel syndrome patients.

Umael Khan, Ingeborg Brønstad, Eline Margrete Randulff Hillestad, Elisabeth K Steinsvik, Trygve Hausken, Birgitte Berentsen, Gülen Arslan Lied

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Umael KhanSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Ingeborg BrønstadSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Eline Margrete Randulff HillestadNational Centre for Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway.
Elisabeth K SteinsvikSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Trygve HauskenSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Birgitte BerentsenSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Gülen Arslan LiedSection of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) as well as glucagon-like peptide-1 (GLP-1) have independently been implicated in irritable bowel syndrome (IBS) pathophysiology. However, there is a lack of studies that assess how low FODMAP diet affects circulating GLP-1 levels in IBS patients. Methods: Thirty patients with either diarrhea or mixed type IBS were recruited and undertook low FODMAP diet for 12 weeks. Plasma GLP-1 levels, IBS Severity Scoring System (IBS-SSS), body weight and FODMAP intake were assessed before and after the 12-week dietary intervention. Key results: Following a low FODMAP diet, average IBS-SSS and body weight were reduced ( Conclusion: Our study indicates that a 12-week low FODMAP diet may increase plasma glucagon-like peptide-1 levels in IBS patients. The underlying mechanism for this increase remains to be understood.

Indexed as

brain-gutFODMAPGLP-1gut microbiotaIBSincretins

Identifiers

PMID40880735
PMCPMC12380553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.