ArticleMaedica2025
Effect of Dietary Intervention in Paediatric Patients with Chronic Spontaneous Urticaria: Open Labelled Randomised Controlled Trial.
Article in Maedica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07632040 (Clinical Response to a Histamine- and Pseudoallergen-Restricted Diet in Patients With Chronic Urticaria), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Response to a Histamine- and Pseudoallergen-Restricted Diet in Patients With Chronic Urticaria
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Chronic spontaneous urticaria (CSU) is a skin disorder characterized by itchy wheal, angioedema or both that persists for over six weeks. 'Pseudoallergens' in food induce hypersensitive reactions similar to true allergic reactions and are linked to CSU. These consist of food additives, vasoactive amines (histamine) and a few natural substances in fruits, vegetables and spices. This study aimed to investigate if dietary restriction (pseudoallergen-free and low histamine diet) can improve the clinical outcome in paediatric CSU patients. Materials and methods: The present open-label randomized control trial was conducted in a paediatric tertiary care centre of Eastern India from September 2021 to August 2022. Paediatric CSU patients (n=140) attending the centre were randomly allocated to one of two treatment interventions: DR group (n=70, drug) or DRDI group (n=70, drugs and dietary intervention). Both groups were compared at baseline. The weekly urticaria activity score (UAS7) was calculated by trained parents. All data were entered in an Excel spreadsheet. T-test was used to compare the UAS7 of both groups at baseline, three and six weeks of treatment. Results: There was no significant difference in demographic characteristics, clinical features, laboratory parameters and weekly urticaria activity score (UAS7) between groups at baseline. After six weeks of treatment, the UAS7 of patients in the DRDI group was lower as compared to those in the DR group (8.80±4.27 vs 10.19±4.66), though statistically insignificant (t=1.79, p=0.07). Conclusion: Pseudoallergen-free diet is a safe and cost-effective measure to decrease CSU patients' symptoms.
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