Evidence map›Paper›PMID 40880664›Full record

ArticleRSC chemical biology2025

Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for

Atsushi Hashimoto, Yuma Kunitomo, Ittoku Kikuchi, Hiroki Yamada, Keiko Kobayashi, Kazuhiro Soshiroda, Hiromi Aman, Yasuaki Kimura, Junichiro Yamamoto, Yasuhisa Shiraishi and 3 more

Abstract read
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Atsushi HashimotoInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0009-0006-2844-0712
Yuma KunitomoInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0009-0000-8307-1645
Ittoku KikuchiInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.
Hiroki YamadaInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0009-0009-0231-2706
Keiko KobayashiInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.
Kazuhiro SoshirodaInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.
Hiromi AmanInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.
Yasuaki KimuraDepartment of Chemistry, Graduate School of Science, Nagoya University Furo, Chikusa Nagoya 464-8602 Japan.ORCID https://orcid.org/0000-0002-3609-602X
Junichiro YamamotoInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0009-0008-9188-0715
Yasuhisa ShiraishiInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0000-0002-8235-1976
Satoshi UchidaDepartment of Advanced Nanomedical Engineering, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8510 Japan.ORCID https://orcid.org/0000-0001-8726-0478
Hiroshi AbeDepartment of Chemistry, Graduate School of Science, Nagoya University Furo, Chikusa Nagoya 464-8602 Japan.ORCID https://orcid.org/0000-0003-0048-3789
Hiroto IwaiInnovation Center, Research Division Kyowa Kirin Co., Ltd. 3-6-6 Asahi, Machida Tokyo 194-8533 Japan hiroto.iwai.sk@kyowakirin.com.ORCID https://orcid.org/0009-0008-8781-3077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The poly(A) tail plays a crucial role in mRNA stability and translation efficiency. Chemical modification of the poly(A) tail is a promising approach for stabilizing mRNA against deadenylation. In this study, we investigated the effect of poly(A) chemical modifications using phosphorothioate (PS), 2'-fluoro (2'-F), 2'-

Identifiers

PMID40880664
PMCPMC12381655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.