ArticleFrontiers in cellular and infection microbiology2025
Dysbiosis of gut and urinary microbiota in urolithiasis patients and post-surgical cases.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multi-habitat microbiome profiling identifies habitat-dependent alterations and complementary discriminatory information in urolithiasis.Frontiers in cellular and infection microbiology · 2026Article
- The gut-kidney axis in calcium oxalate nephrolithiasis: Nutritional and microbial insights.Northern clinics of Istanbul · 2026Review
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Authors and funding
12 authors.
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Abstract
Background: Research on the microbial roles in urolithiasis primarily focuses on the intestinal microbiota. This study analyzed urine and fecal samples from three cohorts: healthy controls (Control), patients with urinary stones (US), and postoperative patients (PS). We conducted 16S rRNA sequencing analysis to evaluate the variations in microbial communities among these groups during urinary stone production and therapy processes. Results: In fecal microbiota, alpha diversity was lower in the stone group versus the control group, with the postoperative group showing the lowest diversity. The β diversity analysis revealed some differences in the microbial community structure of individuals with different health conditions. LEfSe and Wilcoxon analyses were utilized to discover species that exhibited significant differences between groups. Conclusions: Alterations in urinary and intestinal microbiota may indicate urolithiasis status and treatment response. Future studies should explore microbiota modulation (e.g., probiotics) as an adjunctive strategy, while antibiotic stewardship is warranted to minimize microbiota disruption.
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