Evidence map›Paper›PMID 40880552›Full record

ArticleWorld journal of critical care medicine2025

Predictors of lethal outcome in patients with immunoinflammatory diseases hospitalized in the intensive care unit.

Natalia N Abramova, Ilia S Avrusin, Olga P Kozlova, Liudmila A Firsova, Anastasia G Kuleshova, Gleb V Kondratiev, Dmitry O Ivanov, Yury S Aleksandrovich, Mikhail M Kostik

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Article in World journal of critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Natalia N AbramovaDepartment of Anesthesiology, Resuscitation and Emergency Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Ilia S AvrusinDepartment of Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Olga P KozlovaDepartment of Clinical Mycology, Allergology, and Immunology, North-Western State Medical University Named after I.I. Mechnikov, Saint Petersburg 191015, Russia.
Liudmila A FirsovaDepartment of Propaedeutics of Childhood Diseases, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Anastasia G KuleshovaDepartment of Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Gleb V KondratievDepartment of Oncology, Pediatric Oncology and Radiation Therapy, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Dmitry O IvanovDepartment of Neonatology, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Yury S AleksandrovichDepartment of Anesthesiology, Resuscitation and Emergency Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.
Mikhail M KostikDepartment of Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia. kost-mikhail@yandex.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic immunoinflammatory diseases can affect multiple systems and organs. They have a severe course and severe complications, causing multiple organ failure and death. Quite often these patients are required to be hospitalized in the intensive care unit (ICU). Approximately 50% of patients with multisystem inflammatory syndrome associated with coronavirus disease 2019 in children and systemic lupus erythematosus need admission to the ICU.

aimTo find early predictors of death in patients with immunoinflammatory diseases who are hospitalized in the ICU.

methodsThe retrospective continuous cohort study included 51 patients (23 males, 28 females) with immunoinflammatory diseases, including multisystem inflammatory syndrome associated with coronavirus disease 2019 (

resultsThirteen patients (25.5%) died within 39 (17; 62) days after ICU admission. Patients with an unfavorable outcome were significantly older and were admitted to the ICU later than patients who survived (30 days

conclusionIdentifying patients at high risk of an unfavorable outcome is the subject of the most careful monitoring and appropriate treatment program. Avoiding ICU stays for patients with systemic rheumatic diseases, close monitoring, and preventing invasive mycosis might improve the outcome in children with systemic immune-mediated diseases.

Indexed as

ChildrenDeathsFatal outcomesIntensive care unitInvasive mycosisMultisystem inflammatory syndrome associated with coronavirus disease 2019Pediatric rheumatic diseasesSystemic inflammation

Identifiers

PMID40880552
PMCPMC12305108

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