ArticlePloS one2025
Association between AST/ALT ratio and the risk of gestational diabetes mellitus in Korean pregnant women.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Early-pregnancy ALT, AST, and GGT in relation to gestational diabetes: a GGT-focused association pattern.Frontiers in endocrinology · 2026Article
- Association of the GLM7 composite metabolic index with gestational diabetes mellitus in early pregnancy: a secondary analysis of a Korean prospective pregnancy cohort.Frontiers in nutrition · 2026Article
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3 authors.
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Abstract
backgroundThe aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio is associated with insulin resistance (IR) and diabetes mellitus, but its association with gestational diabetes mellitus (GDM) has been less well-studied.
objectiveOur study aimed to investigate whether the AST/ALT ratio is associated with GDM in a population of pregnant Korean women.
methodsThe study was a secondary analysis of a prospective cohort study. It included 623 pregnant women who were at 10-14 weeks of gestation between November 2014 and September 2016. We downloaded and analyzed the data in October 2024. A total of 575 singleton pregnant women were included after excluding missing variables. All participants were followed up until the birth of their children. AST/ALT ratio was obtained by dividing AST by ALT. AST/ALT ratio was used as a continuous variable, and a quartile categorical variable was used for analysis. Logistic regression models were used to estimate the relationship between AST/ALT ratio and GDM. Subgroup and sensitivity analyses were conducted to explore the stability of this relationship. Restricted cubic spline (RCS) curve fitting was employed to investigate potential non-linear associations.
resultsPregnant women were stratified into quartiles based on their AST/ALT ratios, with the following cutoff values: Q1 (<1.167), Q2 (1.167-1.499), Q3 (1.5-1.818), and Q4 (>1.818). The overall mean AST/ALT ratio across all participants was 1.6 ± 1.0. After adjusting for confounders, the AST/ALT ratio was negatively associated with GDM (OR=0.45, 95% CI: 0.2-0.99), with results confirmed by sensitivity and subgroup analyses.
conclusionThis study demonstrated that a lower AST/ALT ratio in early pregnancy was independently and negatively associated with the risk of GDM. The AST/ALT ratio may serve as a potential early biomarker to identify pregnant women at higher risk of GDM, contributing to targeted preventive strategies.
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