Evidence map›Paper›PMID 40880474›Full record

ArticleScience advances2025

Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia.

Ivo Fabrik, Petra Spidlova, Lukas Prchal, Daniela Fabrikova, Ina Viduka, Valentina Marecic, Vlada Filimonenko, Radek Sleha, Marie Vajrychova, Rudolf Kupcik and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ivo FabrikBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.ORCID 0000-0002-3027-1253
Petra SpidlovaDepartment of Molecular Pathology and Biology, Military Faculty of Medicine, University of Defence, 500 01 Hradec Kralove, Czechia.ORCID 0000-0002-9417-636X
Lukas PrchalBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.ORCID 0000-0001-9698-4478
Daniela FabrikovaBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.
Ina VidukaDepartment of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0002-5176-5850
Valentina MarecicDepartment of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0001-6246-8547
Vlada FilimonenkoElectron Microscopy Core Facility, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czechia.ORCID 0000-0002-7939-5572
Radek SlehaDepartment of Epidemiology, Military Faculty of Medicine, University of Defence, 500 01 Hradec Kralove, Czechia.ORCID 0000-0001-7359-9147
Marie VajrychovaBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.ORCID 0000-0002-9495-8046
Rudolf KupcikBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.ORCID 0000-0002-4199-6321
Ondrej SoukupBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czechia.ORCID 0000-0001-6376-8701
Tomas RousarDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, 532 10 Pardubice, Czechia.ORCID 0000-0002-6893-821X
Anetta HärtlovaWallenberg Centre for Molecular and Translational Medicine, Department of Microbiology and Immunology at Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-8152-4361
Marina SanticDepartment of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0003-4138-3581
Jiri StulikDepartment of Molecular Pathology and Biology, Military Faculty of Medicine, University of Defence, 500 01 Hradec Kralove, Czechia.ORCID 0000-0002-4790-2365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) hijacked by intracellular bacteria contribute to pathogen dissemination and immunopathology. How bacteria achieve DC subversion remains largely unknown. Here, we describe the mechanism used by tularemia agent

Indexed as

Dendritic CellsFrancisella tularensisGlutamic AcidInflammationMitochondriaReactive Oxygen SpeciesTularemiaAnimalsHumansMiceMice, Inbred C57BLGlutamic AcidReactive Oxygen Species

Identifiers

PMID40880474
PMCPMC12396335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.