ArticlePloS one2025
Motivation, barriers, and willingness to participate in clinical trials for novel cancer treatments among the Vietnamese population.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel therapeutic approaches are actively explored and evaluated, but applying these innovations to practice depends critically on the recruitment of volunteers for clinical trials. This study aimed to assess the motivations, barriers, and willingness of the general population in Vietnam to participate in clinical trials for novel cancer treatments.
methodsThis analytical cross-sectional research involved the distribution of self-administered online and printed questionnaires to residents across central and southern Vietnam in December 2024. A structured 23-item questionnaire was developed based on a literature review of studies from the UK, US, and Germany. Items were culturally adapted for Vietnam and translated using a WHO-adapted four-step process, including forward translation, expert panel review, cognitive interviews with 25 participants, and final revision. Face and content validity were assessed during this process. Logistic regression analysis was conducted to determine the factors associated with the respondents' willingness to participate in the aforementioned clinical trials.
resultsThe questionnaires were completed by 851 participants, with the majority aged 40-50 years (30.3%). The respondents also indicated a preference for treatments with prior clinical use and coverage by health insurance (65.6%). The primary motivation for participation was intensive monitoring of conditions (83.7%). The most frequently cited barrier were concerns regarding the high risk associated with less-tested treatments (74.1%). A total of 33.6% expressed a willingness to participate in clinical trials, but fewer (18.9%) were willing to allow such involvement for their children or other family members. Finally, Kinh ethnicity, good health, and positive attitudes toward novel cancer treatments were significantly associated with an increased willingness to participate in clinical trials (p < 0.05).
conclusionThis study provides critical insights into the motivation of and barriers to participation in clinical trials for novel cancer treatments. Addressing barriers and promoting motivations can contribute to supporting cancer clinical trial conductions and then improving cancer treatment effectiveness in Vietnam.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.