SynthesisNutrition reviews2025
Overall Evidence for Milk-Derived Proteins and Peptides in Blood after Digestion: A Systematic Review.
Synthesis in Nutrition reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Blood-based biomarkers of protein digestibility, utilization, and nitrogen excretion in animals: Concepts, evidence, and applications.Veterinary and animal science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
contextMilk and dairy products are rich in protein components, including bioactive peptides and proteins that may play crucial roles in influencing human health. Despite extensive research on the nutritional profile and bioactive components of milk, there is no consensus on the presence or absence of milk-derived proteins or peptides in the blood post-consumption of milk or dairy products. Many studies have identified milk-derived proteins or peptides from blood, but there is no existing catalog of all the proteins and peptides found from the blood matrix. Various types of study design exist, but they consider several types of animals, feed sources, and other variables. In addition, there is currently no existing catalog, or review, encompassing all milk-derived proteins and peptides found in blood, or the methods for identifying them from a blood matrix.
objectiveThe objective of this article was to create a comprehensive list of milk-derived proteins and peptides detected in blood after digestion of milk or other dairy products. DATA SOURCES: A search strategy was developed and adapted for each database searched (Web of Science and PubMed) and for the gray literature search (Google Scholar). Additionally, the references for all review papers identified by the searches were screened for potential inclusion. DATA EXTRACTION: Studies were reviewed for relevance by at least 2 authors independently. Relevant studies underwent data extraction and were evaluated for risk of bias by 1 researcher. The articles were managed in COVIDENCE. Data extraction and risk-of-bias assessments were performed in Excel. DATA ANALYSIS: A total of 108 studies were included, of which 102 detected milk-derived proteins or peptides in blood, mainly intact immunoglobulin G (IgG), β-lactoglobulin (BLG), α-lactalbumin (ALA), and casein peptides.
conclusionThis review will inform researchers about (i) established milk-derived proteins and peptides that can be found in blood from consuming dairy, (ii) bioactive milk-derived peptides with potential to exert bioactivity systemically, and (iii) what methods are optimal for use in identifying absorbed proteins and peptides. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration No. CRD42023476956.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.