Evidence map›Paper›PMID 40880124›Full record

ArticleFEBS open bio2025

Characterization of the thermophilic xylanase Fsa02490Xyn from the hyperthermophile Fervidibacter sacchari belonging to glycoside hydrolase family 10.

Nicole Torosian, Jonathan K Covington, Allison M Cook, Nancy O Nou, Marike Palmer, Ritesh Mewalal, Miranda Harmon-Smith, Ian K Blaby, Jan-Fang Cheng, Matthias Hess and 1 more

Abstract read
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In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicole TorosianSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Jonathan K CovingtonSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Allison M CookSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Nancy O NouSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.ORCID https://orcid.org/0000-0003-4758-8131
Marike PalmerSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Ritesh MewalalUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, CA, USA.
Miranda Harmon-SmithUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, CA, USA.ORCID https://orcid.org/0000-0002-3980-1820
Ian K BlabyUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, CA, USA.
Jan-Fang ChengUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, CA, USA.ORCID https://orcid.org/0000-0001-7315-7613
Matthias HessDepartment of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0003-0321-0380
Brian P HedlundSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.ORCID https://orcid.org/0000-0001-8530-0448

Funding

NASA 80NSSC17K0548NASA 80NSSC20M0043NASA 80NSSC21M0157National Science Foundation & Directorate for Biological Sciences DBI REU 1757316National Science Foundation & Directorate for Biological Sciences HRD-1712523U.S. Department of Energy & Office of Science DE-AC02-05CH11231
6 · The paper itself

Abstract

Fervidibacter sacchari is an aerobic hyperthermophile belonging to the phylum Armatimonadota that degrades a variety of polysaccharides. Its genome encodes 117 enzymes with one or more annotated glycoside hydrolase (GH) domain, but the roles of these putative GHs in polysaccharide catabolism are poorly defined. Here, we describe one F. sacchari enzyme encoding a GH10 domain, Fsa02490Xyn, that was previously shown to be active on Miscanthus, oat β-glucan, and beech-wood xylan, with optimal activity at 90-100 °C. We show that Fsa02490Xyn is also active on birch-wood xylan and gellan gum. The pH range on beech-wood xylan was 4.5 to 9.5 (pH

Indexed as

Endo-1,4-beta XylanasesGlycoside HydrolasesBacterial ProteinsHydrogen-Ion ConcentrationPhylogenySubstrate SpecificityXylansBacterial ProteinsEndo-1,4-beta XylanasesGlycoside HydrolasesXylansArmatimonadotaGH10glycoside hydrolasehyperthermophilexylanase

Identifiers

PMID40880124
PMCPMC12485897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.