ArticleMovement disorders clinical practice2026
Subthalamic Theta-Alpha Local Field Potentials in OFF-Levodopa Dystonia in Parkinson's Disease.
Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The potential of utilizing Local Field Potential (LFP) in diagnosis and management of Parkinsonism's hallmark symptoms: a comprehensive review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDystonia affects an estimated 30% of patients with Parkinson's Disease (PD). While pallidal theta-alpha oscillations (4-10 Hz) have been found to characterize primary dystonia compared to beta oscillations (12-30 Hz) in PD, the electrophysiology underlying dystonia in PD remains unexplored.
objectivesExplore the electrophysiology underlying dystonia in PD.
methodsSubthalamic nucleus (STN) local field potentials (LFPs) in PD patients with and without dystonia were compared using a bidirectional deep brain stimulation (DBS) device.
resultsFourteen PD patients with bilateral STN-DBS were included, four (28.6%) with lower extremity dystonia. In 3/7 hemispheres affected by dystonia (42.9%), maximum amplitude LFP activity occurred in the theta-alpha band (4-10 Hz). Conversely, all 21 hemispheres not associated with dystonia had maximum STN activity around the beta-band (11.5-35 Hz, P = 0.011).
conclusionsSTN theta-alpha activity in patients with PD may be associated with dystonic symptoms. Although other motor and non-motor features may correlate with STN theta-alpha, this biomarker warrants further investigation in closed-loop DBS.
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