ArticleMovement disorders clinical practice2025
Plasma Neurofilament Light Chain and TNF-α Correlate with Motor Features in Isolated REM Sleep Behavior Disorder.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Reduced serum interleukin-2 associates with higher motor severity and along with CD4 T cell alterations may be an early event in isolated REM Sleep Behaviour Disorder.Brain, behavior, & immunity - health · 2026Article
- No evidence for genetic role of the tumor necrosis factor pathway in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson's Disease.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIsolated RBD (iRBD) is a prominent early marker of Parkinson's disease and related disorders.
objectivesEvaluate biomarkers of inflammation and axonal damage people with iRBD for disease progression.
methodsPlasma samples from 27 video-polysomnography confirmed iRBD patients and 25 controls were analyzed for inflammatory biomarkers (CRP, IL-6, TNF-α, IFN-γ, IL-1β) and NfL using the Meso Scale Discovery platform.
resultsPeople with iRBD had elevated plasma TNF-α and IL-6 (p = 0.013 and p = 0.051). In the iRBD group, plasma NfL was associated with objective motor tests: Timed Up and Go (R
conclusionsWe report evidence of peripheral inflammation in early synuclein-related disease processes, and association of plasma NfL and TNF-α with motor dysfunction in iRBD patients, suggesting possible association with increased risk of phenoconversion.
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