ArticleMetabolomics : Official journal of the Metabolomic Society2025
Pre-partum feeding strategies affect colostrum metabolite levels related to nitrogen and energy metabolism in Holstein dairy cows.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Applications of metabolomics in cow health assessment.Metabolomics : Official journal of the Metabolomic Society · 2025Review
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3 authors.
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Abstract
introductionCow colostrum synthesis takes place during the last month of pregnancy. Its composition is influenced by individual and environmental factors, such as cow parity, feeding, season and environmental conditions. Therefore, colostrum metabolomic profiling may provide information about the physiological status of cows around calving.
objectivesThe cow colostrum metabolome was analyzed to determine whether its variability could be used to elucidate the cows' physiological status around calving and provide insights into the outcomes of cow transition programs.
methodsThe factors assessed included a control feeding based on grass-clover silage and barley straw (FAR), two phase feedings based on acidified corn silage and canola cake, supplemented with magnesium chloride (MGC) or magnesium chloride and ammonium chloride (NH
resultsOur results show that calving season influenced the levels of 14 metabolites. Independent of seasonal variation, acidified corn silage diets resulted in consistent decreased levels of tryptophan, acetate and cytidine, while the non-acidified grass-based diet resulted in increased concentrations of fucose.
conclusionsAlthough colostrum is physiologically regulated, our findings, for the first time, indicate that the four feeding strategies induce shifts in fucose, tryptophan, acetate and cytidine levels, reflecting the energy and nitrogen metabolism of cows before parturition.
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