Evidence map›Paper›PMID 40879959›Full record

ReviewMedical oncology (Northwood, London, England)2025

The diverse roles of circular RNAs in cholangiocarcinoma.

Yanhui Zhang, Xue Xing, Jia Liu, Li Hou, Yi Xu, Bo Zhai, Haonan Feng, Changwen Guo, Gang Tan, Daolin Ji

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanhui ZhangDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Xue XingDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Jia LiuDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Li HouDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Yi XuDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Bo ZhaiDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Haonan FengDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Changwen GuoDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Gang TanDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China. ttgg4698@sina.com.ORCID http://orcid.org/0000-0001-8096-4798
Daolin JiDepartment of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China. jdl0799@126.com.ORCID http://orcid.org/0000-0001-9029-3801

Funding

China Postdoctoral Science Foundation, China 2021M693823Excellent Youth Project of Natural Science Foundation of Heilongjiang Province, China YQ2022H011Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University, China HYDSYYXQN202102 and HYDSYYXQN202301Heilongjiang Postdoctoral Science Foundation, China LBH-Z20180Hong Kong Scholars Program, China XJ2020012National Natural Science Foundation of China, China 82102911National Natural Science Foundation of China, China 82472743 and 82300921Postgraduate Research & Practice Innovation Program of Harbin Medical University, China YJSCX2023-283HYDthe Fundamental Research Funds for the Provincial Universities, China 2021-KYYWF-0259The matic Research Support Scheme of State Key Laboratory of Liver Research, The University of Hong Kong, China SKLLR/TRSS/2022/08the Natural Science Foundation of Heilongjiang Province, China PL2024H154
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a malignant tumor that develops in the extrahepatic bile duct, that is, from the left and right hepatic ducts to the lower end of the common bile duct. Because of its indeterminate etiology, difficulties in the diagnosis of early lesions, easy invasion and metastasis and resistance to chemotherapeutic drugs, the trend of mortality rate deterioration of patients with CCA has not been fundamentally reversed. And the molecular mechanisms underlying the development of CCA are not well characterized. Circular RNA (CircRNA) is an endogenous non-coding RNA with a circular structure. Recent studies have found circRNA involved in multiple physiological processes and participated in the proliferation, invasion, metastasis, immunomodulation, angiogenesis, biometabolism, and chemoresistance of many malignancies, including CCA, pancreatic cancer, liver cancer, and gastric cancer. In this review, we summarize what has been published so far to be related to the biogenesis, functions, and characteristics of circRNAs in CCA and the potential clinical prospects.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaRNA, CircularBiomarkers, TumorHumansBiomarkers, TumorRNA, CircularCholangiocarcinomaCircular RNAPrognosisProliferationSponge function

Identifiers

PMID40879959

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.