Evidence map›Paper›PMID 40879948›Full record

ReviewAdvances in experimental medicine and biology2025

Lifestyle Interventions in Frailty.

Fernando Millan-Domingo, Jose Viña

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Fernando Millan-DomingoDepartment of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0002-7541-0704
Jose ViñaDepartment of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain. jose.vina@uv.es.ORCID https://orcid.org/0000-0001-9709-0089

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty is a major concern in gerontology and geriatrics as it may lead to disability. At the time of writing this review, 30% of the population over 65 in Europe (an in other parts of the world) are dependent on the care of other persons. It is estimated that this percentage may grow to 50% by 2050.A note of hope is that frailty (unlike aging itself) can be prevented and even reverted. Here we have reviewed two of the major lifestyle changes that are useful to treat age-associated frailty: nutrition and physical exercise. A common characteristic of both interventions is that they must be personalized. Precision interventions are now quite common in areas like oncology. A major evolution in gerontology and geriatrics should be placing more emphasis on precision, personalized interventions. Here, we have outlined general approaches to the prevention and treatment of age-associated frailty. These must be tailored to the specific needs and characteristics of each individual.

Indexed as

AgingExerciseFrail ElderlyFrailtyLife StyleAgedHumansAgeDeficiencyDisabilityHealthspanNutritionProteinsVitamins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.