ReviewAdvances in experimental medicine and biology2025
Skeletal Muscle Damage and Inflammation.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- [EstradiolZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Regenerative Medicine: Advanced Therapy for Muscle Tissue Restoration.International journal of molecular sciences · 2026Review
- Tceal7 is a BRG1-regulated target of calcineurin signaling that promotes myoblast differentiation.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle is an extremely plastic tissue that can respond to a variety of insults. If the insult is sufficient, it may reduce damage to the skeletal muscle. Damage to skeletal muscle is associated with an inflammatory response. This inflammatory response is required for optimal regeneration. There are several models used to induce damage to skeletal muscle from eccentric muscle actions to myotoxin injections. While the method of inducing damage may vary the inflammatory response is similar. Upon damage, circulating immune cells are activated and infiltrate the tissue. The first to arrive is the neutrophil followed by the macrophage. The neutrophil clears debris and releases pro-inflammatory signals which facilitate the recruitment of macrophages. Macrophages are recruited and begin as pro-inflammatory macrophages (M1) continuing to facilitate the clearance of debris before macrophage polarization occurs in which they become anti-inflammatory macrophage (M2). The anti-inflammatory macrophages facilitate the myogenic response critical for optimal regeneration. Disruptions to the inflammatory response will directly affect the ability of the skeletal muscle to recover from injury.
Indexed as
Identifiers
40879941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.