ArticleBulletin of experimental biology and medicine2025
Changes of α-Synuclein Localization in a Neuronal Precursor Graft in the Rat Model of 6-OHDA-Induced Parkinsonism.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In the experiment with transplantation of neuronal mesencephalic precursors derived from induced pluripotent stem cells into the striatum of rats with unilateral 6-OHDA destruction of the substantia nigra, we evaluated changes in the immunostaining for α-synuclein during differentiation and maturation of grafted neurons 1, 3, and 6 months after the surgery. The content of α-synuclein in transplanted neurons peaked by the third month after surgery, as well as changes in the nuclear-cytoplasmic ratio of α-synuclein in neurons by the 3rd and 6th months relative to the 1st month after transplantation were revealed. Changes in α-synuclein localization and content were associated with a gradual decrease in doublecortin expression and an increase in immunostaining for neuronal enolase and synaptophysin as the graft matured. The high content of total α-synuclein in developing neurons may be a key factor of spreading of α-synuclein toxic species in graft cells and a cause of cell damage.
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