Cotton Rat Model of Respiratory Syncytial Virus Infection.

Jonathan Miller, Stefan Niewiesk

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan MillerDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

Stefan NiewieskDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. niewiesk.1@osu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hispid cotton rat (Sigmodon hispidus) has demonstrated excellent translational and predictive value in the study of respiratory syncytial virus (RSV). While the cotton rat model has many advantages over the mouse model, unfamiliarity with the species can serve as a deterrent to its use. Here, we review the most common protocols for studying RSV in the cotton rat model, including housing and handling, anesthesia and intranasal infection, drug administration, blood draws, and postmortem tissue collection. Using these basic protocols, investigators can pursue downstream applications similar to those available in other animal models, limited only by available species-specific or cross-reactive reagents.

Indexed as

Disease Models, AnimalRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsSigmodontinaeAnimalsHumansAnimal modelCotton ratRespiratory syncytial virusSigmodon hispidus

Identifiers

PMID40879916

DOI10.1155/2017/9050754

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.