Evidence map›Paper›PMID 40879915›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Visualizing Respiratory Syncytial Virus Replication in Live Mice.

Jean-François Eléouët, Marie Galloux, Marie-Anne Rameix-Welti

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jean-François EléouëtUnité de Virologie et Immunologie Moléculaires (VIM) UMR0892, INRAE-UVSQ-Université Paris-Saclay, Jouy-en-Josas, France. jean-francois.eleouet@inrae.fr.
Marie GallouxUnité de Virologie et Immunologie Moléculaires (VIM) UMR0892, INRAE-UVSQ-Université Paris-Saclay, Jouy-en-Josas, France.
Marie-Anne Rameix-WeltiUnit M3P Institut Pasteur, Université Paris-Saclay, Université de Versailles St. Quentin, Université Paris Cité, UMR 1173 (2I), INSERM; Assistance Publique des Hôpitaux de Paris, Centre National de Référence Virus des Infections Respiratoire (CNR VIR), Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modeling human respiratory syncytial virus (RSV) infection in vivo is an essential step in the search for novel vaccines, antiviral therapies, or preventive measures against RSV disease. The most commonly used experimental models of RSV infection are rodent models, in particular, inbred BALB/c mice and cotton rats (Bem et al., Am J Physiol Lung Cell Mol Physiol 301(2): L148-L156, 2011; Taylor, Vaccine 35(3): 469-480, 2017; Altamirano-Lagos, Front Microbiol 10: 873, 2019). However, depending on the RSV strain and viral titer, infection of mice with RSV can result in few or no symptoms, with viral load being estimated by RT-qPCR on lung tissue. By allowing the monitoring of the spread and intensity of the infection in the same animal over time, the use of recombinant RSV expressing the firefly luciferase represents a major advance in the study of RSV replication in the murine model.

Indexed as

Respiratory Syncytial VirusesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsVirus ReplicationAnimalsDisease Models, AnimalHumansLungMiceMice, Inbred BALB CViral LoadIn vivo modelLuciferaseLuminescenceMicePreclinical modelReplicationVisualizing

Identifiers

PMID40879915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.