ArticleMethods in molecular biology (Clifton, N.J.)2025
Respiratory Syncytial Virus Fusion Activity Syncytia Assay.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Generation of human-induced pluripotent stem cell-derived lung organoids for modeling respiratory syncytial virus infection and pulmonary injury.Frontiers in immunology · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
The methods detailed here measure the membrane fusion activity of viral fusion proteins and are optimized for the respiratory syncytial virus (RSV). RSV utilizes a class I fusion protein (F) to facilitate fusion between a viral and cellular membrane to allow viral entry into host cells. This process is carried out with the assistance of the glycoprotein (G), which attaches to the host-cell surface, allowing F to interact with the target cell. The F protein then undergoes conformational changes, which drive membrane fusion, thus creating a path for viral entry. The fusogenic activity of viral fusion proteins can be quantified by observing and measuring syncytia formation via wide-field microscopy. Syncytia are multinucleated cell masses formed by cell-cell membrane fusion, which in this case are driven by viral fusion proteins expressed on the host-cell surface.
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Registered trials
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