ArticleMetabolomics : Official journal of the Metabolomic Society2025
Effect of acute administration of melatonin immediately after physical exercise on the amino acid profile of rat's skeletal muscle and liver.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMelatonin has been proposed to aid recovery following physical exercise; however, few studies have investigated its effects on tissue amino acid profile.
objectiveThis study aimed to evaluate the effects of post-exercise melatonin administration on tissue amino acid concentration and metabolic regulation.
methodsThirty Wistar rats engaged in a 60-minute swimming session at 90% of their individual maximal aerobic capacity (iMAC), followed by the intraperitoneal administration of melatonin (EM; 10 mg·kg⁻
resultsNo significant effects were observed in the liver tissue. However, in skeletal muscle, melatonin significantly increased the levels of several amino acids, including arginine, glutamic acid, glutamine, ornithine, proline, and serine. Additionally, glycine levels were elevated 3 h post-exercise (EM3 > Ex3; p < 0.05), whereas methionine levels were reduced 24 h post-exercise in the melatonin group compared to control groups (EM24 < Ex24; p < 0.01).
conclusionMelatonin modulated the post-exercise amino acid profile in skeletal muscle, enhancing the levels of key metabolites involved in recovery and metabolic regulation, with no effects observed in liver tissue. These findings suggest a muscle-specific role for melatonin in supporting metabolic recovery after exercising.
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