Suggestive Contribution of Sequence Signal Gene Variants of TGF-β1 in Development of Type 1 Diabetes, Diabetic Neuropathy, and Modulation of Lipid Profile.

Esma Mihoubi, Faiza Bouldjennet, Habiba Amroun, Malha Azzouz, Chafia Touil-Boukoffa, Rachida Raache

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Esma MihoubiLaboratory of Cellular and Molecular Biology, Cytokine and NO Synthase, Team Faculty of Biological Sciences, University of Science and Technology, Houari Boumediene (USTHB), BP 32 EL Alia, 16011, Algiers, Algeria. esmamih@gmail.com.

Faiza BouldjennetResearch Laboratory Biodiversity Biotechnology, Environment and Sustainable Development, University M'hamed Bougara, Boumerdes, Algeria.ORCID http://orcid.org/0000-0002-8217-720X

Habiba AmrounCentral Laboratory, Nafissa Hamoud Hospital, Algiers, Algeria.ORCID http://orcid.org/0000-0002-6708-3045

Malha AzzouzEndocrinology Department of Bainem Hospital, Algiers, Algeria.ORCID http://orcid.org/0000-0001-7682-7758

Chafia Touil-BoukoffaLaboratory of Cellular and Molecular Biology, Cytokine and NO Synthase, Team Faculty of Biological Sciences, University of Science and Technology, Houari Boumediene (USTHB), BP 32 EL Alia, 16011, Algiers, Algeria.ORCID http://orcid.org/0000-0001-7728-2147

Rachida RaacheLaboratory of Cellular and Molecular Biology, Cytokine and NO Synthase, Team Faculty of Biological Sciences, University of Science and Technology, Houari Boumediene (USTHB), BP 32 EL Alia, 16011, Algiers, Algeria.ORCID http://orcid.org/0000-0003-1735-3729

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6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM) and its associated complications result from the interplay between genetic and environmental factors, with inflammation playing a central role in their pathogenesis. This study aimed to assess the association between TGF-β1 gene variants and T1DM, as well as its neuropathy, in the Algerian population. A case-control study was conducted, analyzing 344 blood samples. The TGF-β1 rs1800470 and rs1800471 were genotyped using the PCR-SSP method. Genotype and allele frequencies were compared among participants, and phenotype-genotype interactions were determined.The results revealed that the TGF-β1 rs1800470 CC genotype was significantly more frequent in patients (OR = 2.08, p = 0.016), while the GC genotype was significantly more frequent in controls (OR = 0.49, p = 0.001). The C allele (OR = 2.97, p < 0.0001) and the GC genotype (OR = 2.93, p = 0.0003) of the TGF-β1 rs1800471 were significantly more frequent in T1DM patients, while the G allele (OR = 0.34, p < 0.0001) and GG genotype (OR = 0.32, p < 0.0001) were more frequent in controls. Furthermore, the GG genotype of rs1800471 was associated with diabetic neuropathy (OR = 3.30, p = 0.03), and carrying at least one copy of the minor C allele was linked to higher levels of total cholesterol (p = 0.0096) and triglycerides (p = 0.001). Based on these data, we suggest an association between the TGF-β1 variants rs1800470 and rs1800471 and susceptibility to T1DM. Furthermore, the rs1800471 variant may be involved in the development of diabetic neuropathy with a possible impact on lipid profiles.

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesLipidsPolymorphism, Single NucleotideTransforming Growth Factor beta1AdultCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedLipidsTGFB1 protein, humanTransforming Growth Factor beta1Diabetic neuropathyLipid profileTGF-β1 gene variantsType 1 diabetes

Identifiers

PMID40879861

DOI10.1016/j.jdiacomp.2009.07.007

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