ArticleJournal of molecular histology2025
Cardioprotective effects of ghrelin and Wharton's jelly-derived mesenchymal stem cells, alone and in combination, in doxorubicin-induced myocardial injury in rats.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases represent one of the most serious health issues, accounting for worldwide morbidity and mortality. Doxorubicin (DOX) induces cardiotoxicity through the formation of free radicals. Stem cell therapy appears to be a promising alternative to existing treatments for myocardial injury, as it can produce growth factors and cytokines that are involved in wound healing. Besides its orexigenic properties, ghrelin was proven to have a cardiovascular protective effect. The present study was designed to compare the possible protective role of ghrelin to Wharton jelly-derived mesenchymal stem cells (WJ-MSCs) as well as their combined effect in doxorubicin-induced cardiotoxicity in rats. Forty adult male albino rats were divided into five groups: Group (I): normal control group, Group (II): DOX induced cardiotoxicity group, Group (III): ghrelin treated group, Group (IV): MSCs treated group and Group (V): ghrelin and MSCs (combined) treated group. Cardiac enzymes, oxidative stress markers, apoptotic markers in cardiac tissue and cardiac performance parameters using Langendorff apparatus and echocardiography, were assessed. At the end of the experiment, histopathological evaluation of the injured myocardium was conducted using hematoxylin and eosin (H&E), Masson’s trichrome staining, and immunohistochemical analysis for nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). Our results revealed a significant amelioration of the aforementioned parameters almost towards normal values in the three treatment groups. Histopathological examination and immunohistochemical assessment of Nrf2 & HO-1 revealed improvement in the three treated groups, particularly those receiving stem cell therapy.
Indexed as
Identifiers
40879836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.