ArticleJournal of molecular histology2025
Ephrin-B1 and EphB4 expression and localization in steroidogenic cells of mouse adrenal gland.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Erythropoietin-producing hepatocellular (Eph) receptors and their ligands ephrin are membrane-bound molecules that modulate diverse cellular functions in various tissues. We recently reported the co-expression of Efnb1 (ephrin-B1) and Ephb4 (EphB4) in steroidogenic cells of the ovary. Based on these previous findings, we examined the expression and localization of ephrin-B1 and EphB4 in steroidogenic cells of the mouse adrenal gland using RT-PCR and immunofluorescence techniques. To the best of my knowledge, ephrin-B1 and EphB4 expression patterns in the adrenal gland are virtually unknown. We found that ephrin-B1 and EphB4 were co-expressed in steroidogenic cells of zona glomerulosa (zG) and zona fasciculata (zF) in the adrenal cortex of mice. Ephrin-B1 and EphB4 were also co-expressed in cells of x-zone (xZ) in female mice. We also found that ephrin-B1 and EphB4 expression in zG was strong and weak respectively. Ephrin-B1 and EphB4 expression in cells of zF were faint in cells of both mice while strong in juxtamedullary cells of zF in male mice. Ephrin-B1 and EphB4 expression were faint and weak in xZ in female mice respectively. The study represents the first expression analysis of ephrin-B1 and EphB4 in steroidogenic cells in the adrenal glands of the male and female mice.
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