Evidence map›Paper›PMID 40879744›Full record

ArticleCellular and molecular life sciences : CMLS2025

sTLR9 on maternal Circulating immune cells as a negative regulatory phenotype during pregnancy.

Hong Wang, Wenting Lu, Mengru Zhu, Yongli Yu, Liying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hong WangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P.R. China.
Wenting LuDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P.R. China.
Mengru ZhuDepartment of Neonatology and Institute of Pediatrics, Children's Medical Center, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, P.R. China.
Yongli YuDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P.R. China. yyl@jlu.edu.cn.
Liying WangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P.R. China. wangliy@jlu.edu.cn.ORCID http://orcid.org/0000-0001-9061-6914

Funding

the National Nature Scientific Foundation of China 31670937the National Nature Scientific Foundation of China 81471888
6 · The paper itself

Abstract

TLR9 is an intracellular receptor that can also be localized to the cell surface, called sTLR9. sTLR9 is thought to have a negative immunomodulatory effect, which is conductive to the maintenance of immune tolerance. Since pregnancy is a physiological process accompanied with inflammation experienced by pregnant women while maintaining immune tolerance to the fetus, the change in sTLR9 of immune cells during pregnancy are worth studying. In this study, we first found that with the progress of pregnancy, the most significant change in PWBCs of pregnant women was the increasing percentage of neutrophils (Neu%) accompanied by the decreasing sTLR9

Indexed as

NeutrophilsToll-Like Receptor 9AnimalsFemaleHumansImmune ToleranceMiceOligodeoxyribonucleotidesPhenotypePregnancyCPG-oligonucleotideOligodeoxyribonucleotidesTLR9 protein, humanToll-Like Receptor 9Immune toleranceInflammatory regulationPeripheral white blood cells (PWBCs)Pregnant maternal immune responseSurface toll-like receptor 9 (sTLR9)-expressing immune cells

Identifiers

PMID40879744
PMCPMC12397482

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.