Evidence map›Paper›PMID 40879650›Full record

ArticleChemMedChem2025

Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N'-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives.

Priam-Amedeo Houngbedji, Daria Elżbieta Nawrot, Ondřej Janďourek, Klára Konečná, Martin Novák, Pavla Paterová, Pavel Bárta, Martina Hrast Rambaher, Eva Novotná, Carlo Castellano and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Priam-Amedeo HoungbedjiFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0009-0002-7011-4102
Daria Elżbieta NawrotFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0002-8858-1529
Ondřej JanďourekFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0003-4633-2062
Klára KonečnáFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0001-5670-7767
Martin NovákBiomedical Research Centre, University Hospital Hradec Králové, Sokolská 581, 500 05, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0001-9692-7641
Pavla PaterováDepartment of Clinical Microbiology, University Hospital Hradec Králové, Sokolská 581, 500 05, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0003-0192-7345
Pavel BártaFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0001-5445-5658
Martina Hrast RambaherFaculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, SI-1000, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0003-0488-2445
Eva NovotnáFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.
Carlo CastellanoDepartment of Chemistry, University of Milan, Via Golgi 19, 20133, Milan, Italy.ORCID https://orcid.org/0000-0002-7497-0670
Matteo MoriDepartment of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.ORCID https://orcid.org/0000-0002-7491-1494
Fiorella MeneghettiDepartment of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.ORCID https://orcid.org/0000-0002-6511-7360
Monika ZáhorszkáDepartment of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15, Bratislava, Slovakia.ORCID https://orcid.org/0000-0002-8542-5272
Jana KordulákováDepartment of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15, Bratislava, Slovakia.ORCID https://orcid.org/0000-0003-2834-0165
Jan ZitkoFaculty of Pharmacy in Hradec Králové, Charles University, Ak. Heyrovského 1203, 500 03, Hradec Králové, Czech Republic.ORCID https://orcid.org/0000-0003-0104-9925

Funding

Charles University SVV 260 666European Union - Next Generation EU - National Institute of Virology and Bacteriology LX22NPO5103Grant Agency of Charles University 230 623University Hospital Hradec Kralove 00179906
6 · The paper itself

Abstract

A series of 33 (E)-N'-benzylidenepyrazine-2-carbohydrazides and their derivatives were synthesized and tested for biological activity. Benzylidene derivatives with 2-OH substitution on the phenyl ring (18: R = 2-OH, 21: R = 2,3-diOH, and 22: R = 2,4-diOH) exhibit various biological activities. Compounds 18 and 21 demonstrate antimycobacterial activity against Mycobacterium tuberculosis H37Ra, M. tuberculosis H37Rv, and M. aurum, with minimum inhibitory concentration values ranging from 15.625 to 62.5 μg mL

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsAntitubercular AgentsHydrazinesPyrazinesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisStructure-Activity RelationshipAnti-Bacterial AgentsAntineoplastic AgentsAntitubercular AgentscarbohydrazideHydrazinesPyrazinesantimycobacterialsantitumor agentsiron chelatorsmedicinal chemistrypyrazine‐2‐carbohydrazides

Identifiers

PMID40879650
PMCPMC12479386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.