ArticleMovement disorders clinical practice2026
Pallidothalamic Tractotomy after Pallidotomy for Medication-Refractory Dystonia: Preliminary Short-Term Results from a Case Series of Five Patients.
Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThere is limited data regarding the role of pallidothalamic tract (PTT) lesioning after failure of pallidotomy.
objectivesTo report the role of unilateral PTT lesioning in refractory generalized dystonia following bilateral pallidotomy and hemi-dystonia following unilateral pallidotomy.
methodsA single-center retrospective case series.
resultsFive patients underwent unilateral PTT lesioning after the failure of pallidotomy to control dystonia, including status dystonicus in one case. The interval between pallidotomy and PTT lesioning ranged from 2 to 90 months. Pre-PTT surgery, BFMDRS-M scores ranged from 20 to 87, and BFMDRS-D scores ranged from 8 to 23. Immediately post-PTT surgery, improvement was observed in four patients, with objective improvements ranging between 57.5 and 93.3% in the BFMDRS-M score. Two patients developed adverse effects: one experienced a mild worsening of post-pallidotomy dysarthria, and another developed impaired hand dexterity.
conclusionsOur initial experience suggests that unilateral PTT lesioning holds promise as an option for lesional surgery following pallidotomy, in refractory dystonia.
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