Trial reportPsycho-oncology2025
An HRQOL Proof-Of-Concept Analysis of the eHealth TOGETHER Intervention for Adolescent and Young Adult Cancer Survivors: A Brief Report.
Trial report in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study to Develop a Group-Based E-Health Intervention for Young Adult Cancer Survivors
Developing and Pre-Testing an eHealth Group Intervention for Young Adult Cancer Survivors
Adapting and Testing an eHealth Platform to Deliver a Group Intervention for Young Adult Cancer Survivors
Improving Young Adult Cancer Survivors' Mental Health with an EHealth Group Intervention
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundAdolescent and young adult (AYA) cancer survivors ages 18-39 report elevated stress and poor health-related quality of life (HRQOL), yet few evidence-based stress management interventions exist that meet their specific needs. Our team designed TOGETHER, a 10-week eHealth group-delivered behavioral intervention designed to improve HRQOL via stress management skills training. To date, TOGETHER has been delivered to seven groups of AYAs, and its feasibility and acceptability have been well established.
aimsThis proof-of-concept analysis explored TOGETHER's impact on patient-reported outcomes among AYAs.
methodsParticipants were English-speaking AYAs aged 18-39 who were diagnosed with cancer while aged 15-39 and had completed curative treatment within the past five years. Patient-reported outcomes were assessed at baseline and post-intervention and included HRQOL, stress management skills self-efficacy, coping strategies, and depression and anxiety symptoms. Pre-to-post-intervention changes were assessed with paired-samples t-tests among those with complete data (n = 39) and using a series of imputation strategies. The proportion of participants achieving clinically meaningful change was computed when possible.
resultsParticipants (N = 51) had an average age of 29 years and were predominantly female (78%), White (69%), and non-Hispanic (80%). HRQOL significantly improved from pre-to post-intervention with small-to-moderate effect sizes (gs ranged from 0.32-0.60), and more than half of participants (51%-59%) demonstrated clinically meaningful improvement. Statistically significant improvements were found for stress management skills self-efficacy, coping, and depression symptoms, but not anxiety symptoms.
conclusionsResults provide proof-of-concept evidence that TOGETHER can meaningfully improve patient-reported outcomes among AYA survivors, supporting continued evaluation of the intervention.
trial registrationClinicalTrials.gov; NCT05048316, NCT05054569, NCT05597228, NCT05952492.
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