Evidence map›Paper›PMID 40879585›Full record

ArticleJACC. Asia2025

Prognostic Value of Functional Incomplete Revascularization in Patients Undergoing Valve Surgery With Coronary Artery Disease.

Fang Zhang, Wei Gao, Wenshuo Wang, Runda Wu, Yan Xia, Jingpu Wang, Qiyu Zhang, Jinying Zhou, Rende Xu, Zhangwei Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fang ZhangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Wei GaoDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Wenshuo WangDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Runda WuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Yan XiaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Jingpu WangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Qiyu ZhangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Jinying ZhouDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Rende XuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Zhangwei ChenDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Yongxin SunDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Shengxian TuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Chunsheng WangDepartment of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: wang.chunsheng@zs-hospital.sh.cn.
Chenguang LiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China. Electronic address: li.chenguang@zs-hospital.sh.cn.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary angiography remains standard for assessing lesions in valve surgery patients with concomitant coronary artery disease.

objectivesThis study assessed the prognostic value of functional evaluation using quantitative flow ratio in these patients.

methodsConsecutive patients undergoing valve surgery (January 2016-December 2021) with ≥1 vessel stenosis (50%-90%) were included. Patients were categorized into complete revascularization (CR) or incomplete revascularization (ICR) groups by functional and traditional anatomical criteria. The primary endpoint was major adverse cardiovascular events ([MACE]; all-cause death, myocardial infarction, unplanned revascularization, stroke).

resultsA total of 750 patients were enrolled in the study, and 244 (32.5%) underwent combined bypass surgery. In the entire cohort, 547 patients (72.9%) met anatomical CR criteria, and 560 patients (74.7%) met functional CR criteria. After median follow-up of 3.0 years (Q1-Q3: 2.0-5.0 years). MACE were significantly increased in the functional ICR group than that in the functional CR group (20.5% [95% CI: 15.4%-26.8%] vs 10.9% [95% CI: 8.6%-13.7%]; HR: 1.98; 95% CI: 1.26-3.11; P<0.001). Meanwhile, no significant differences in MACE rates between the anatomical ICR group and the CR group (16.3% [95% CI: 11.8%-21.9%] vs 12.2% [95% CI: 9.8%-15.3%]; HR: 1.35; 95% CI: 0.87-2.10; P = 0.153). In multivariable regression analysis, functional ICR was an independent predictor for MACE (adjusted HR: 1.63; 95% CI: 1.01-2.64; P = 0.038) compared with functional CR.

conclusionsFunctional ICR in patients undergoing valve surgery with coronary artery disease is associated with increased MACE. These findings support using functional assessment to guide revascularization decisions.

Indexed as

coronary artery bypass graftfunctional incomplete revascularizationphysiological assessmentquantitative flow ratiovalve surgery

Identifiers

PMID40879585
PMCPMC12790059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.