Evidence map›Paper›PMID 40879546›Full record

ArticleFuture medicinal chemistry2025

Synthesis, crystal structure, anticancer activity and computational studies of novel Pyrazolo[4',3':5,6]pyrano[2,3-

Younesse Ait Elmachkouri, Ezaddine Irrou, Imane Yamari, Samir Chtita, Yahya Toubi, Mohamed F AlAjmi, Ali Oubella, Joel T Mague, Nada Kheira Sebbar, Mohamed Labd Taha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Younesse Ait ElmachkouriLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.
Ezaddine IrrouLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.
Imane YamariLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca, Casablanca, Morocco.
Samir ChtitaLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca, Casablanca, Morocco.
Yahya ToubiLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.
Mohamed F AlAjmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ali OubellaLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.
Joel T MagueDepartment of Chemistry, Tulane University, New Orleans, LA, USA.
Nada Kheira SebbarLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.
Mohamed Labd TahaLaboratory of Organic and physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Department of Chemistry, Ibn Zohr University, Agadir, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe search for effective anticancer agents remains a major goal in medicinal chemistry. This study aims to synthesize and evaluate new pyrazolo[4',3':5,6]pyrano[2,3- MATERIALS &

methodsCompounds

resultsCompounds

conclusionsThe synthesized pyrazolopyranopyrimidine derivatives, particularly

Indexed as

Antineoplastic AgentsPyrazolesPyrimidinesCell Line, TumorCell ProliferationCrystallography, X-RayDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsPyrazolesPyrimidinesADME-T predictionEGFR inhibitionin vitro anticancer activitymolecular dockingPyrazolopyranopyrimidinesstructural characterization

Identifiers

PMID40879546
PMCPMC12582053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.