Evidence map›Paper›PMID 40879545›Full record

ArticlePhysical chemistry chemical physics : PCCP2025

Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding.

Vito F Palmisano, Claudio Agnorelli, Shirin Faraji, Juan J Nogueira

Abstract read
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vito F PalmisanoInstitute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany. shirin.faraji@hhu.de.
Claudio AgnorelliUnit of Psychiatry, Department of Molecular Medicine, University of Siena, Siena 53100, Italy.
Shirin FarajiInstitute of Theoretical and Computational Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany. shirin.faraji@hhu.de.
Juan J NogueiraDepartment of Chemistry, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, 7, 28049 Madrid, Spain. juan.nogueira@uam.es.ORCID http://orcid.org/0000-0001-7419-5670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychedelic compounds can induce rapid-acting and long-lasting antidepressant benefits. Understanding the role of their hallucinatory effects is crucial for shaping the future trajectory of antidepressant drug development. Photoswitchable compounds targeting the 5-HT

Indexed as

HallucinogensReceptor, Serotonin, 5-HT2ACell Membrane PermeabilityDrug DesignHumansLightLysergic Acid DiethylamideProtein BindingHallucinogensLysergic Acid DiethylamideReceptor, Serotonin, 5-HT2A

Identifiers

PMID40879545
PMCPMC12396349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.