ArticleHuman brain mapping2025
Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Distinct neural substrates of obsessions and compulsions in adolescent obsessive compulsive disorder.Translational psychiatry · 2026Article
- Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.Human brain mapping · 2025Article
- Functional reorganization of brain networks from childhood to adolescence: A multi-level approach.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
6 authors.
Funding
Abstract
Understanding functional brain development during childhood and adolescence is essential for identifying typical neurodevelopmental trajectories. While resting-state fMRI (rs-fMRI) has become a key tool in developmental neuroscience, few studies have jointly examined multiple functional metrics to comprehensively characterize typical brain maturation across youth. We analyzed rs-fMRI data from 395 neurotypical participants aged 6-20 years from the ABIDE I and II datasets. Voxel-wise analyses were conducted using three complementary rs-fMRI metrics: fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and voxel-mirrored homotopic connectivity (VMHC). Data were harmonized across sites using ComBat and CovBat methods implemented in DPABI to minimize scanner-related variability. Correlation analyses and ANOVA/ANCOVAs were performed to examine developmental age effects. Our results revealed a general pattern of declining local and interhemispheric connectivity with increasing age, across all measures. fALFF decreases were most pronounced in the medial orbitofrontal, caudate, medial occipital cortex, and cerebellum (peak r = -0.210); ReHo showed reductions in the insula and caudate (peak r = -0.169); and VMHC declines were observed in the putamen, cerebellum, superior parietal lobules, and caudate (peak r range = -0.206 to -0.187). These findings outline a developmental trajectory characterized by increasing functional integration and network specialization from late childhood through adolescence. The combined use of fALFF, ReHo, and VMHC provides a robust multitechnical framework for characterizing typical brain development and offers a valuable benchmark for identifying developmental deviations in clinical populations.
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