ArticleMicrobiology spectrum2025
Recombination alters the receptor binding and furin cleavage site in novel bat-borne HKU5-CoV-2 coronavirus.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A divergent betacoronavirus with a functional furin cleavage site in South American bats.Nature communications · 2026Article
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10 authors.
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Abstract
HKU5-CoV-2 is a new bat-infecting coronavirus phylogenetically related to MERS-CoV. It has recently been confirmed that HKU5-CoV-2 can enter human cells and organoids IMPORTANCE: HKU5-CoV-2 is a newly discovered bat coronavirus related to MERS-CoV that can infect human cells using the ACE2 receptor, raising concerns about possible transmission from animals to humans. This study provides the first proof that recombination occurs in HKU5-CoV-2 spike protein, which leads to the changes at position 498 in the RBD-which directly interacts with the human ACE2-and at position 722/723 and 729 in the FCS, may impact how efficiently the virus infects people. These mutations might help the virus adapt to animals or humans and spread more effectively. Our research shows that recombination is important in shaping HKU5-CoV-2's ability to infect bats and potentially humans.
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