Evidence map›Paper›PMID 40879335›Full record

ArticleeLife2025

Mesolimbic dopamine ramps reflect environmental timescales.

Joseph R Floeder, Huijeong Jeong, Ali Mohebi, Vijay Mohan K Namboodiri

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Memory erasure by dopamine-gated retrospective learning.bioRxiv : the preprint server for biology · 2026
    Article
  6. A brief history of dopamine prediction errors.Frontiers in computational neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Joseph R FloederNeuroscience Graduate Program, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0002-6800-7730
Huijeong JeongDepartment of Neurology, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0003-1219-4191
Ali MohebiDepartment of Neurology, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-7291-3448
Vijay Mohan K NamboodiriNeuroscience Graduate Program, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0002-6674-610X

Funding

Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
Prospective and retrospective learning in orbitofrontal cortexR01MH129582 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Vijay Mohan K Namboodiri · 2022 to 2026
$2.2M
Neural encoding of associative learning by orbitofrontal cortex circuitsR00MH118422 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI K NAMBOODIRI, VIJAY MOHAN · 2020 to 2022
$747k
Alfred P Sloan Foundation Alfred P Sloan FellowshipNational Science Foundation GRFPNIMH NIH HHS R00 MH118422NIMH NIH HHS R00MH118422NIMH NIH HHS R01 MH129582NIMH NIH HHS R01MH129582NINDS NIH HHS T32 NS115706Pew Charitable Trusts Pew Biomedical ScholarshipUniversity of California, San Francisco Discovery Fellowship
6 · The paper itself

Abstract

Mesolimbic dopamine activity occasionally exhibits ramping dynamics, reigniting debate on theories of dopamine signaling. This debate is ongoing partly because the experimental conditions under which dopamine ramps emerge remain poorly understood. Here, we show that during Pavlovian and instrumental conditioning in mice, mesolimbic dopamine ramps are only observed when the inter-trial interval is short relative to the trial period. These results constrain theories of dopamine signaling and identify a critical variable determining the emergence of dopamine ramps.

Indexed as

Conditioning, ClassicalDopamineLimbic SystemAnimalsConditioning, OperantMaleMiceMice, Inbred C57BLTime FactorsDopamineDopaminedopamine ramplearningmouseneuroscience

Identifiers

PMID40879335
PMCPMC12396814

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.