Evidence map›Paper›PMID 40879334›Full record

ArticleJournal of the American Geriatrics Society2025

Preliminary Data From a Geriatrician-Led Program for Orthopedic Co-Managed Hip Fracture Patients Using Zoledronic Acid.

Karen Chahal, Jessica Nguyen, Diviya Rajesh, Trevor McBroom, Katiri T Wagner, Michael McTague, Lewis Lipsitz, Edward Kenneth Rodriguez, John Wixted, Sarah D Berry

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karen ChahalBeth Israel Deaconess Medical Center, Department of Medicine, Division of Gerontology & Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0006-8058-967X
Jessica NguyenUniversity of Virginia School of Medicine, Charlottesville, Virginia, USA.
Diviya RajeshHarvard Medical School, Boston, Massachusetts, USA.
Trevor McBroomHarvard Combined Orthopedic Residency Program Harvard Medical School, Boston, Massachusetts, USA.
Katiri T WagnerBeth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Division of Orthopedic Trauma & Harvard Medical School, Boston, Massachusetts, USA.
Michael McTagueBeth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Division of Orthopedic Trauma & Harvard Medical School, Boston, Massachusetts, USA.
Lewis LipsitzBeth Israel Deaconess Medical Center, Department of Medicine, Division of Gerontology & Harvard Medical School, Boston, Massachusetts, USA.
Edward Kenneth RodriguezBeth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Division of Orthopedic Trauma & Harvard Medical School, Boston, Massachusetts, USA.
John WixtedBeth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Division of Orthopedic Trauma & Harvard Medical School, Boston, Massachusetts, USA.
Sarah D BerryBeth Israel Deaconess Medical Center, Department of Medicine, Division of Gerontology & Harvard Medical School, Boston, Massachusetts, USA.

Funding

Greater Boston Medical Student Training in Aging ResearchT35AG038027 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DRIVER, JANE A, MCLAUGHLIN-GAVIN, CARA · 2010 to 2024
$991k
Mentoring Patient-Oriented Research to Prevent Injury in Older AdultsK24AG070106 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI Sarah Dyer Berry · 2021 to 2026
$735k
All of Us Research Program NIH (US) MSTAR 5T35AG038027-12NIA NIH HHS AG070106NIA NIH HHS K24 AG070106NIA NIH HHS T35 AG038027
6 · The paper itself

Abstract

backgroundHip fractures are increasing as the U.S. population ages and result in significant morbidity, mortality, and cost. Despite guidelines recommending osteoporosis treatment after hip fracture, few patients receive treatment. To address this unmet need, our large, tertiary care, academic hospital initiated an inpatient osteoporosis treatment program with Zoledronic Acid (ZA) led by a single geriatrician co-managing patients with hip fracture admitted to the orthopedic trauma service. This study describes the program's implementation and preliminary data.

methodsA prospective cohort of older adults (>/= 65 years) with surgically repaired hip fractures at a single academic center were included from September 12th, 2022, through May 17th, 2024. The ZA program was initiated by geriatrics in collaboration with other specialties, including nursing and pharmacy. Co-managed hip fracture patients were screened for ZA. Eligibility criteria included creatinine clearance >/= 35 mL/min and Vitamin D level >/= 20 ng/mL. The RE-AIM framework was utilized to evaluate the program's implementation: Reach (number of patients admitted, screened and eligible), effectiveness (eligible patients who received ZA, reasons for ineligibility), adoption (time spent) and implementation (program cost).

resultsDuring a twenty-month period, 232 hip fracture patients with a mean age of 83.8 years were admitted to co-managed care, of which 74% were female. 148 patients were screened for ZA; 67 (45.3%) were eligible, and 58 (39.2%) received ZA prior to hospital discharge. The most common reasons for ineligibility were low vitamin D (32.1%), inadequate kidney function (21%) and previous or current osteoporosis treatment in the outpatient setting (29.6%). No adverse reactions or delays in discharge were noted among treated patients. On average, 30 min were spent on screening and treatment.

conclusionA co-managed inpatient ZA program led by a single geriatrician appears to be a feasible strategy to treat osteoporosis among hospitalized patients with hip fracture.

Indexed as

Bone Density Conservation AgentsGeriatriciansHip FracturesOsteoporosisZoledronic AcidAgedAged, 80 and overFemaleHumansMaleProspective StudiesBone Density Conservation AgentsZoledronic Acidco‐managed carehip fractureinpatientosteoporosiszoledronic acid

Identifiers

PMID40879334
PMCPMC13062795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.