ArticleBrain and behavior2025
Inflammatory Biomarkers Predictive of Psychopathology in Children With Physical Illness.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Physical illnesses, mental or neurodevelopmental disorders, and multimorbidity in children: results from the Canadian Health Survey on Children and Youth.Social psychiatry and psychiatric epidemiology · 2026Article
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5 authors.
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Abstract
backgroundWhile evidence shows that children with chronic physical illness are at increased risk for psychopathology, the causal mechanisms linking physical and mental illness early in life remain unconfirmed.
objectiveGiven a lack of longitudinal studies investigating inflammatory responses in the context of child psychopathology, and none that specifically sample children with chronic physical illness, this study evaluated associations between inflammatory biomarkers and psychopathology in children with chronic physical illness over a 48-month period.
methodsData come from 128 children enrolled in the Multimorbidity in Children and Youth across the Life-course (MY LIFE) study who provided baseline dried blood samples for biomarker analysis and completed the 48-month assessment (mean age 11.0 years, 50.0% male). Psychopathology was measured using parent and child reports on the Emotional Behavioural Scales. Dried blood samples were assayed using the Bio-Plex 200 system. Linear mixed models, adjusted for age and sex, estimated associations between inflammatory biomarkers and child psychopathology over time.
resultsNo differences in biomarker concentrations across physical illnesses were found, except for interleukin (IL)-1β, which showed lower levels in the neurological subgroup (χ
conclusionFindings are not definitive evidence of a causal mechanism for physical-mental comorbidity in children but are consistent with reports in other populations. The predictive power of G-CSF, GM-CSF, and IL-6 supports the need for broader blood panels and routine mental health assessment, particularly for children on treatments that disrupt regulatory inflammatory pathways.
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