ArticleBrain and behavior2025
A Synergistic Examination of Excitatory-Inhibitory Balance in First-Episode Schizophrenia Merging 7-Tesla Magnetic Resonance Spectroscopic Imaging and Magnetoencephalography.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia.The American journal of psychiatry · 2026Review
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10 authors.
Funding
Abstract
introductionExcitatory/inhibitory (E/I) imbalance is a proposed neural disruption in schizophrenia supported by magnetic resonance spectroscopic imaging (MRSI) evidence of altered gamma-aminobutyric acid (GABA) and glutamate (Glu) levels. However, there exists a paucity of data linking these abnormalities to impaired in vivo brain function putatively reflecting E/I imbalance. Here, associations between GABA/Glu and the evoked early auditory gamma-band response (EAGBR) were examined in first-episode schizophrenia (FESz).
methodsTwelve FESz underwent resting-state 7T-MRSI and magnetoencephalography (MEG) recorded during an auditory oddball task. MRSI spectra and source-localized MEG data were extracted from overlapping regions of left (LH) and right (RH) superior temporal sulcus. Associations between evoked EAGBR power and GABA/Glu, GABA/Cre, and Glu/Cre ratios were assessed. The Brief Psychiatric Rating Scale (BPRS) and Global Functioning: Role/Social (GF: Role/Social) scales were collected.
resultsGABA/Glu ratios were inversely correlated with EAGBR power (LH: ρ = -0.87; RH: ρ = -0.85). LH GABA/Glu ratios were also inversely correlated with BPRS scores (ρ = -0.64) and positively correlated with GF: Social (ρ = 0.64) scores while RH EAGBR power was positively correlated with BPRS scores (ρ = 0.70). Stepwise linear regressions suggest these relationships were driven primarily by GABA concentrations.
conclusionAssociations in FESz between GABA/Glu ratios, clinical ratings, and EAGBR power suggests this evoked gamma-band response reflects cortical hyperexcitability within the auditory system that is closely tied to disease debility at this early illness stage. These data highlight the potential of merging high-precision, in vivo neuro-chemical assays via 7-Tesla MRSI and physiological measures from MEG to validate established cellular models of disease.
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