Evidence map›Paper›PMID 40879319›Full record

ArticlePediatric blood & cancer2025

Human Lymphatic Endothelial Cells Expressing NRAS

Dermot A Fox, C Griffin McDaniel, Patricia Pastura, Timothy D Le Cras

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. RAS Inhibitor RMC-7977 Blocks Vascular Overgrowth of NRASJournal of cellular and molecular medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dermot A FoxDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
C Griffin McDanielDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Patricia PasturaDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Timothy D Le CrasDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0001-8538-2703

Funding

Pathogenesis and Treatment of Kaposiform LymphangiomatosisR01HL156866 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMOTHY DAVID LE CRAS · 2022 to 2026
$3.3M
NHLBI NIH HHS R01 HL156866
6 · The paper itself

Abstract

Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly characterized by lymphatic overgrowth and dysfunction. The goal of this study was to determine how the NRAS

Indexed as

Endothelial CellsGTP PhosphohydrolasesKasabach-Merritt SyndromeLymphangiogenesisMembrane ProteinsCell MovementCell ProliferationCells, CulturedHemangioendotheliomaHumansSarcoma, KaposiGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanrasopathiesvascular anomalyvascular malformation

Identifiers

PMID40879319
PMCPMC12860489

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.