Evidence map›Paper›PMID 40879306›Full record

ArticleJournal of the American Geriatrics Society2025

Life-Prolonging Treatment Preferences and Their Association With Health Care Utilization and End-Of-Life Experiences in Older Adults.

Lesli E Skolarus, Chun Chieh Lin, Sara Hassani, Ran Bi, James F Burke

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lesli E SkolarusDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3088-9838
Chun Chieh LinDepartment of Neurology, Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4470-2648
Sara HassaniDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ran BiDepartment of Neurology, Ohio State University, Columbus, Ohio, USA.
James F BurkeDepartment of Neurology, Ohio State University, Columbus, Ohio, USA.

Funding

Understanding Implications of End-of-life Preferences to Optimize Advance Care Planning Among Older AmericansR01AG059733 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURKE, JAMES FRANCIS, SKOLARUS, LESLI ELIZABETH · 2018 to 2022
$3.1M
National Institute on Aging (NIH/NIA) R01AG059733NIA NIH HHS R01 AG059733
6 · The paper itself

Abstract

backgroundPeople markedly differ in their preferences for life-prolonging treatments (LPT). We explored the association between LPT preferences and healthcare utilization and end-of-life (EOL) experiences.

methodsWe conducted a retrospective cohort study using data from 5373 older adults in the National Health and Aging Trends Study (NHATS) linked to Medicare/Medicaid. Among them, 1564 died, and 1124 had proxies who completed the Last Month of Life module. We categorized LPT preferences (accept or reject) in severe disability or pain scenarios, and we assessed healthcare utilization (hospitalization, ICU visits, receipt of LPT, hospice), total cost, and days out of home in the last year of life, place of death, and EOL experiences.

resultsThe average age of respondents was 76.7 years (SD 5.9), 55.1% female, and 7.8% Black people. Sixty-nine percent would reject all LPT; 5.3% would accept LPT only in the severe disability scenario; 15.8% would accept LPT only in the pain scenario; and 9.9% in both. There was no association between LPT preferences and hospitalization, ICU visits, receipt of LPT, or costs. Respondents accepting LPT for pain spent more time away from home (3.4 days, 95% CI: 0.3, 6.6, p = 0.03). Among decedents, preferences were not linked to receipt of LPT, hospice use, or EOL care quality. Those accepting LPT for severe disability and pain had higher odds of dying in a hospital (OR = 1.8, 95% CI 1.1-3, p < 0.03) compared to those who would reject LPT.

conclusionsLPT preferences established in hypothetical scenarios were not associated with health care utilization, cost, or perceived quality of end-of-life. As LPT preferences should influence care, subsequent work, such as understanding preference measurement, real-world preference changes, or the limited opportunity for preferences to influence care, is warranted.

Indexed as

Patient Acceptance of Health CarePatient PreferenceTerminal CareAgedAged, 80 and overFemaleHospice CareHospitalizationHumansMaleMedicareRetrospective StudiesUnited Statesend of lifeolder adultspreferences

Identifiers

PMID40879306
PMCPMC12554839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.