Evidence map›Paper›PMID 40879285›Full record

ArticleInternational forum of allergy & rhinology2025

Dupilumab Initiation for Surgically Refractory Chronic Rhinosinusitis With Nasal Polyps Is Associated With Differential Expression of CLC and Activation of Eicosanoid Pathways.

Christina Dorismond, Rory J Lubner, Daniel H Lofgren, Chandler J Rygalski, Ping Li, Katherine N Cahill, Suman R Das, Mason R Krysinski, Rakesh K Chandra, Justin H Turner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina DorismondDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4333-9763
Rory J LubnerDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-9884-2799
Daniel H LofgrenDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Chandler J RygalskiDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-7197-1822
Ping LiDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Katherine N CahillDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Suman R DasDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mason R KrysinskiDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rakesh K ChandraDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Justin H TurnerDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama-Birmingham, Birmingham, Alabama, USA.
Naweed I ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Age-associated Innate Immune Dysfunction in Chronic RhinosinusitisR01AG065550 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TURNER, JUSTIN H · 2020 to 2024
$3.0M
Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of DiseaseK24AI177947 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Justin H Turner · 2023 to 2026
$457k
Burroughs Wellcome FundNational Institute of Allergy and Infectious Diseases K24AI177947National Institute of Allergy and Infectious Diseases L30AI186158NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NIAID NIH HHS K24 AI177947NIAID NIH HHS L30 AI186158NIA NIH HHS R01 AG065550NIH HHS R01AG065550
6 · The paper itself

Abstract

key pointsAn untargeted transcriptomic analysis provided exploratory insight into key genes and pathways that can be used to help identify patients at risk for surgically refractory chronic rhinosinusitis with nasal polyps (CRSwNP). The Charcot-Leyden crystal gene, periostin and osteopontin-associated pathways, eicosanoid synthesis pathway, and prostaglandin/leukotriene metabolism pathway, among others, are associated with dupilumab prescription for surgically refractory chronic rhinosinusitis and may support early stratification of disease severity in CRSwNP patients.

Indexed as

Antibodies, Monoclonal, HumanizedEicosanoidsNasal PolypsRhinitisSinusitisAdultCell Adhesion MoleculesChronic DiseaseFemaleHumansMaleMiddle AgedRhinosinusitisAntibodies, Monoclonal, HumanizedCell Adhesion MoleculesdupilumabEicosanoidsPOSTN protein, humanchronic rhinosinusitisdifferential gene expressiondupilumabnasal polyptranscriptome

Identifiers

PMID40879285
PMCPMC12581870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.