ArticleCytoskeleton (Hoboken, N.J.)2026
ENKD1 Modulates Skin Elasticity Through Microtubule Stability Regulation.
Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- ENKD1 Modulates Skin Elasticity Through Microtubule Stability Regulation.Cytoskeleton (Hoboken, N.J.) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Skin elasticity is critical for maintaining skin function, yet the molecular mechanisms governing this process remain incompletely understood. Herein, we identify enkurin domain-containing protein 1 (ENKD1) as a key regulator of skin elasticity by modulating microtubule stability in basal keratinocytes. In Enkd1 knockout mice, impaired migration of basal keratinocytes results in reduced epidermal elasticity compared to wild-type controls. Mechanistically, ENKD1 localizes to the centrosome and microtubules, where its expression enhances microtubule stability. Conversely, the absence of ENKD1 destabilizes microtubules, which likely impedes keratinocyte migration and compromises epidermal elasticity. Further investigations suggest that ENKD1 exerts its effects on microtubule stability via EB1. Collectively, these findings establish ENKD1 as a pivotal regulatory factor of mammalian epidermal elasticity, providing new insights into the molecular underpinnings of skin function.
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Registered trials
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