ArticleJournal of the American Geriatrics Society2025
Prevalence and Prognostic Implication of Sarcopenia Among Patients With Stage B Heart Failure: The PAPRIKA-HF Cohort Study.
Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between physical activity and long-term prognosis in older patients with Stage B heart failure.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Relationship between nutrition status and muscle mass and its impact on 1-year mortality in patients with aortic stenosis undergoing transcatheter aortic valve implantation.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Interaction between depressive symptoms and social support on frailty risk among patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- Prevalence and Prognostic Implication of Sarcopenia Among Patients With Stage B Heart Failure: The PAPRIKA-HF Cohort Study.Journal of the American Geriatrics Society · 2025Article
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9 authors.
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Abstract
backgroundThe long-term prognosis of patients with heart failure (HF) remains poor. Most patients with HF are older, and multiple factors involved in geriatric syndromes are associated with worse long-term prognosis. Sarcopenia is a major component of geriatric syndrome. Early diagnosis and therapeutic intervention for sarcopenia are clinically important in patients with HF; however, the prevalence and long-term prognostic impact of sarcopenia in patients with stage B HF remain unclear. This study aimed to determine the prevalence of sarcopenia in older patients with stage B HF and its impact on the long-term prognosis.
methodsThe PAPRIKA-HF study was a multicenter, prospective study that enrolled outpatients ≥ 65 years who were diagnosed with stage B HF. Sarcopenia was assessed based on the Asian Working Group for Sarcopenia 2019 diagnostic criteria. The primary endpoint was a composite endpoint (all-cause mortality, incident myocardial infarction, or hospitalization for heart failure) of > 2 years.
resultsAmong 312 patients (mean age: 78.2 ± 6.5 years, 45% female), 17.7% (56 of 312 patients) had sarcopenia. The rate of the composite endpoint over 2 years was significantly higher in patients with sarcopenia than in those without (25.0% vs. 2.7%, log-rank test, p < 0.0001). Multivariate analysis using the Cox proportional hazards model showed that sarcopenia was an independent predictor of long-term prognosis (hazard ratio: 5.78, 95% confidence interval: 2.16-15.43, p < 0.001).
conclusionsSarcopenia was associated with a worse long-term prognosis in older patients with stage B HF, highlighting the importance of early diagnosis of sarcopenia.
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